基本情况：

侯丽萍，女，副教授，博士，硕士生导师（生物学和生物化学工程方向）。2000年毕业于华南师范大学生命科学学院，获理学学士学位；2003年毕业于华南师范大学生命科学学院，获理学硕士学位；2011年毕业于华南师范大学，获动物学博士学位。2012年起任广州大学生命科学学院教师。广东省动物学会、广东省水产学会会员。

科 研：

主要从事水生生态毒理学研究，利用食蚊鱼与斑马鱼为模式生物，研究水环境中典型有机污染物特别是内分泌干扰物如孕激素、雄激素、糖皮质激素等对水生生物的毒性效应、健康风险评价及毒理机制。主持科研项目包括国家自然科学基金面上基金、国家自然科学基金青年基金、广东省自然科学基金面上项目、广东省海洋与渔业厅攻关项目、广东省教育厅青年创新人才类项目、广州市教育局科技创新项目等。公开发表论文100 多篇，其中 SCI 论文 30 多篇。以第一作者或通讯作者在 《 Environmental Science & Technology 》、《 Science of the Total Environment》、《Aquatic Toxicology》、 《Environmental Pollution》、 《Chemosphere》等国际权威期刊发表论文 28 篇，担任国际期刊《Ecotoxicology and Environmental Safety 》的海外编辑，任 《Aquatic Toxicology》、 《Ecotoxicology and Environmental Safety》、《Scientific Reports》等杂志审稿人。 主讲本科生课程《动物学》、《动物学实验》、《实验动物学》等，主持广州大学校级教育教研项目，指导学生参加“挑战杯”大学生课外学术科技竞赛获得校级三等奖、二等奖，指导本科生参加省级、校级大学生创新训练大赛多次，指导本科生动物学野外实习，生物技术专业毕业实习带队老师。

教学：

主讲本科生课程《动物学》、《动物学实验》、《实验动物学》、《进化生物学》、《营养与健康》、等，主持广州大学校级教育教研项目，指导学生参加“挑战杯”大学生课外学术科技竞赛获得校级三等奖、二等奖，指导本科生参加省级、校级大学生创新训练大赛多次，指导本科生动物学野外实习，生物技术专业毕业实习带队老师。获得“大学生课外学术科技竞赛优秀指导老师”称号。

主要研究项目：

1. 国家自然科学基金面上项目，4217071321，环境孕激素诱导雌性食蚊鱼子代神经发育受损的 DNA 甲基化作用，57 万元，在研，主持。

2. 国家自然科学基金面上项目，41977207，环境孕激素诱导食蚊鱼雄性化的分子机制研究，61 万元，在研，结题。

3. 国家自然科学基金青年基金项目，21607032, 环境中典型雄激素和孕激素对食蚊鱼的内分泌干扰效应和作用机制研究，20 万元， 在研，主持。

4. 广东省渔业局科技攻关项目，A201701B10，宝石鲈受控式循环水集装箱高效健康养殖技术研究，2016/08-2019/08，50万元，在研，主持。

5. 广东省教育厅优秀青年创新人才培育项目，2012A040，广州市污水处理厂排水的雄激素物质污染及对食蚊鱼的毒性机理的研究, 2014/08-2016/08，5万元，已结题，主持。

6. 广东省教育创新强校项目（科技类）（厅级），2012LYM0100，珠江三角洲地区造纸 废水的环境内分泌干扰效应研究, 2012/08-2015/08，3万元，已结题，主持。

7. 横向课题，东江流域典型行业排水毒性评估2016/08-2016/12，26万元，已结题，主持。

8. 广东省海洋生物技术重点实验室开发基金，GPKLMB201603,石斑鱼生态培苗和工厂花养殖技术示范推广，2016/09—2017/12，3万元，已结题，主持。

9. 广东省生产力促进中心项目，专业镇特色产业创新资源数据库创新资源收集与整理，2016/09—2017/12，5万元，已结题，主持。

代表性论文：

1) Ye M.X., Yang J.L, Cai Z.P , Wu J.H , Hou L.P., * The effect of cortisone on female zebraffsh (Dania rerio): Reducing reproductive capacity and offspring survival rate ,Aquatic Toxicology，2024, 277 ,107132

2) Tan J.F., Hou L.P., * Yang L.H., Ye M.X., Geng Y.X., Guo Y.F., Zou H., Effects of cortisone in zebrafish (Danio rerio): Insights into gut microbiota interactions and molecular mechanisms underlying DNA damage and apoptosis, Journal of Hazardous Materials, 2024,478,135576

3) Zhou S.H., Lin Z., Lin H,J., Li C.Y., Liu Z.Y., Hou L.P., * Lian X.Y., Pan C,G.,Liang Y.Q., The impact of co-exposure to polystyrene microplastics and norethindrone on gill histology, antioxidant capacity, reproductive system, and gut microbiota in zebrafish (Danio rerio) ,Aquatic Toxicology, 2024, 273,107018

4) Zou H., Yu H,J., Huang Y,Y., GuoY,F., Ye M,X., Hou L.P., * Chronic exposure to gestodene impairs reproductive system in adult female zebrafish (Dania rerio) ,Chemosphere 2024, 355,141876

5) Li Y.L., Tan Z. Q., Zuo P. Y., Li M.R., Hou, L.P.,*, Xiaolan Wang,* Gestodene causes masculinization of the western mosquitofish (Gambusia affinis): Insights from ovary metabolomics, Science of The Total Environment, 2024, 912, 168693

6) Geng Y.X, Zou H., Guo,Y.F, Huang,M.L, Wu, Y.S, Hou,L.P.,* Chronic exposure to cortisone induces thyroid endocrine disruption and retinal dysfunction in adult female zebrafish (Danio rerio) Science of The Total Environment, 2023, 905, 167022

7) Guo,Y.F. , Liang X.R., Li ,H.S., Ye ,M,X., Zou,H., Hou,L.P.*, Liang, Y.Q.,* Effects of norethindrone on the growth, behavior, and thyroid endocrine system of adult female western mosquitoffsh (Gambusia afffnis) Ecotoxicology and Environmental Safety 2023, 267

8) Tan J.F., Liang C.Y., Guo,Y.F., Zou,H., Guo,Y.Q., Ye J.H., Hou,L.P.*, Xiaolan Wang,* Thyroid endocrine disruption and neurotoxicity of gestodene in adult female mosquitofish (Gambusia affinis) Chemosphere 2023, 313  

9) Li Y. L, Tan Z.Q, Wang X.L* and Hou L.P* Metabolic changes and potential biomarkers in "Candidatus Liberi bacter solanacearum"-infected potato psyllids: implications for psyllid-pathogen interactions Frontiers in Plant Science,2023,14:1-10

10) Tan, J.F., Chen, H.X., Chen, S.D., Hu, J.J., Wang, X.L., Wang, Y.F., Liao, S.L., Chen, P.X., Liang, C.Y., Dai, M.L., Du, Q.P., Hou, L.P.,* 2022. The interactive effects of ethinylestradiol and progesterone on transcriptional expression of genes along the hypothalamus–pituitary– thyroid axis in embryonic zebrafish (Danio rerio)., Science of the Total Environment, 805(150371).

11) Wang, Y.F., Wang, Z. P., Wu, H. X., Hou, L, P., * Liu, Z. Q., * 2022. Reconstruction of spinel Co3O4 by inert Zn 2+ towards enhanced oxygen catalytic activity. Chemical Communication. 58, 637–640.

12) Wang, X.Y., Tan, Z.Q., Chen, S.D., Gui, L., Li, X.C., Ke, D.S., Hou, L.P.,* Jonathan Y.S. Leung., 2021. Norethindrone causes cellular and hepatic injury in zebrafish by compromising the metabolic processes associated with antioxidant defence: Insights from metabolomics, Chemosphere, 275.

13) Chen, S.D., Lin, C.Y., Tan, J.F., Wang, Y.F., Wang, X.Y., Wang, X.L., Liu, L., Li, J.Y., Hou, L.P.,* Liu, J., Jonathan Y.S. Leung., 2021. Reproductive potential of mosquitofish is reduced by the masculinizing effect of a synthetic progesterone, gestodene: Evidence from morphology, courtship behaviour, ovary histology, sex hormones and gene expressions., Science of the Total Environment, 769(144570).

14) Hou, L.P., Chen, S.D., Shi W.J., Chen, H.X., Liang, Y.Q., Wang, X.L., Tan, J.F., Wang, Y.F., Deng, X.K., Zhan, M.J., Long, J.Z., Cai, G.W., Luo, S.W., Zhang, C.P., Liu, J., Jonathan Y.S.Leung; Xie, L.T., 2020. Norethindrone alters mating behaviors, ovary histology, hormone production and transcriptional expression of steroidogenic genes in zebrafish (Danio rerio), Ecotoxicology and Environmental Safety, 195, 110496.

15) Hou, L.P., Chen, S., Chen, H., Ying, G., * Chen, D., Liu, J., Liang, Y., Wu, R., Fang, X., Zhang, C., 2019. Rapid masculinization and effects on the liver of female western mosquitofish (Gambusia affinis) by norethindrone. Chemosphere 216, 94-102.

16) Hou, L.P., Chen, S., Liu, J., * Guo, J., Chen, Z., Zhu, Q., Zhang, W., Xu, G., Liang, Y., Wu, R., 2019. Transcriptomic and physiological changes in western mosquitofish (Gambusia affinis) after exposure to norgestrel. Ecotoxicology and Environmental Safety 171, 579-586.

17) Liu, J., Mei,L.Y., Zhang,W.,L., Daniel, C.W.Tsang., Wei,X.D., Zhou,Y.,T., Xiao,T.F., Jin,W., Hou, L.P., * 2019. Response of microbial communities and interactions to thallium in contaminated sediments near a pyrite mining area Environmental Pollution, 248, 916-928. 18)Liu,J.,Li,N.,Zhang,W.L.,Wei,X.D.,DanielC.W.Tsang,Sun,Y.B.,Luo,X.W.,Bao,Z.A., Zheng,Wang,J., Hou, L.P., * 2019. Thallium contamination in farmlands and common vegetables in a pyrite mining city and potential health risks .Environmental Pollution 248, 906-915.

19) Liu, J., Wang, J., Daniel C.W. T., Xiao,T.F., Chen,Y.H., and Hou, L.P., * 2018. Emerging Thallium Pollution in China and Source Tracing by Thallium Isotope. Environmental Science & Technology 52, 11977−11979.

20) Hou, L.P., Chen, H., Tian, C.E., Liang, Y., Wu, R.R, Zhang, X.M., Fang, X.W., Zhang, C.P., Hu, J.J., Song, L.Y., 2018. Alterations of secondary sex characteristics, reproductive histology and behaviors by norgestrel in the western mosquitofish (Gambusia affinis). Aquatic Toxicology 198, 224-230.

21) Hou, L.P., Chen, H., Tian, C.E., Shi, W.J., Liang, Y., Wu, R.R., Fang, X.W., Zhang, C.P., Liang, Y.Q., Xie, L., 2018. The progestin norethindrone affects sex differentiation and alters transcriptional profiles of genes along the hypothalamic–pituitary–gonadal and hypothalamic–pituitary–adrenal axes in juvenile zebrafish (Dario renio). Aquatic Toxicology 201, 31-39.

22) Hou, L.P., Yang, Y., Shu, H., Ying, G.G., Zhao, J.L., Fang, G.Z., Xin, L., Shi, W.J., Yao, L., Cheng, X.M., 2018. Masculinization and reproductive effects in western mosquitofish (Gambusia affinis) after long-term exposure to androstenedione. Ecotoxicology and Environmental Safety 147, 509-515.

23) Hou, L.P., Shu, H., Lin, L.L., Xu, S.Y., Wu, Y.X., Rong, X.J., Hu, J.J., Song, L.Y., Liang, Y.Q., Chen, H.X., Ying, G.G., Tian, C.E., 2018. Modulation of transcription of genes related to the hypothalamic-pituitary-gonadal and the hypothalamic-pituitary-adrenal axes in zebrafish (Danio rerio) embryos/larvae by androstenedione. Ecotoxicology and Environmental Safety 156, 403-408.

24) Hou, L.P., Xu, H., Ying, G., Yang, Y., Shu, H., Zhao, J., Cheng, X., 2017. Physiological responses and gene expression changes in the western mosquitofish (Gambusia affinis) exposed to progesterone at environmentally relevant concentrations. Aquatic Toxicology 192, 69-77.

25) Hou, L.P., Yang, Y., Shu, H., Ying, G.G., Zhao, J.J., 2017. Changes in Histopathology Enzyme Activities, and the Expression of Relevant Genes in Zebrafish (Danio rerio) Following Long Term Exposure to Environmental Levels of Thallium. Bulletin of Environmental Contamination and Toxicology 99,574–58.

26) Yang, Y., Li, Q.,·Shu, H., Zhou, H.Q., Li, X.,· Hou, L.P., * 2017. Characterization of the melanocortin4 receptor gene from Spinibarbus hollandi and the association between its polymorphisms and S. hollandi growth traits. Fisheries Science, 83, 967-976

27) Hou, L.P., Xie, Y.P., Ying, G.G., Fang, Z.Q., ⁎ , 2011. Developmental and reproductive characteristics of western mosquitofish (Gambusia affinis) exposed to paper mill effluent in the Dengcun River, Sihui, South China, Aquatic Toxicology, 103,140-149.

联系方式

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